abstract：:The exact factors contributing to the pathogenesis of type 2 diabetes remain elusive. Lately, it was suggested that inflammation and activation of the innate immune system could be linked to type 2 diabetes pathogenesis and also to the development of common diabetic complications, mainly atherosclerosis. The aim of th...

journal_title：Diabetes research and clinical practice

authors： Giulietti A,van Etten E,Overbergh L,Stoffels K,Bouillon R,Mathieu C

更新日期：2007-07-01 00:00:00

abstract：:The present study aimed to reveal racial differences in the metabolic pattern of C-peptide and non-esterified fatty acids (NEFA), and in their associations with cardiovascular measures in healthy urban African (102) and Caucasian women (115) from South Africa. An oral glucose tolerance test was performed with measurem...

journal_title：Diabetes research and clinical practice

authors： Reimann M,Schutte AE,Huisman HW,Schutte R,van Rooyen JM,Malan L,Malan NT,Schwarz PE

更新日期：2007-07-01 00:00:00

abstract：:To investigate the effects of sulfonylurea receptor 1 (SUR1) exon 33 (TCC-->GCC, S1369A) polymorphism on responsiveness to gliclazide. About 115 patients with type 2 diabetes were treated with gliclazide for 8 weeks. SUR1 genotypes were tested by Taqman-PCR. After gliclazide treatment, there was association between T/...

journal_title：Diabetes research and clinical practice

authors： Zhang H,Liu X,Kuang H,Yi R,Xing H

更新日期：2007-07-01 00:00:00

abstract：:One of the major public health challenges of the 21st century is type 2 diabetes. WHO estimates that by 2025 as many as 200-300 million people worldwide will have developed the disease. A distressing increase in children is perhaps the most alarming sign of something going wrong. Roughly half of the risk of type 2 dia...

journal_title：Diabetes research and clinical practice

authors： Hussain A,Claussen B,Ramachandran A,Williams R

更新日期：2007-06-01 00:00:00

abstract：AIMS:The aim of the study was to determine physicians' knowledge of specific concepts generally implicated in the pathophysiology of type 2 diabetes (T2D). METHODS:A multiple choice online survey was completed by 847 physicians, of which 516 were engaged in primary care (PCP) and 331 in specialized care (SCP) in the U...

journal_title：Diabetes research and clinical practice

authors： Busse FP,Denti V,Stumvoll M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:To investigate the association between C-reactive protein (CRP) and the risk of developing diabetes in Aboriginal Australians. RESEARCH DESIGN AND METHODS:High sensitivity CRP levels were measured in 620 Aboriginal participants aged 20-74 years free from diabetes at baseline in a remote community in the Nort...

journal_title：Diabetes research and clinical practice

authors： Wang Z,Hoy WE

更新日期：2007-04-01 00:00:00

abstract：AIMS:To estimate the prevalence of the metabolic syndrome using the IDF versus NCEP definition. POPULATION:14222 non-diabetic and 1516 diabetic subjects, aged 25-74 years. RESULTS:The age-standardized prevalence of the IDF metabolic syndrome in non-diabetic men (women) was 12.0% (15.0%), 13.8% (2.5%), 12.8% (17.0%), ...

journal_title：Diabetes research and clinical practice

authors： DECODA Study Group.

更新日期：2007-04-01 00:00:00

abstract：:We investigated whether isoprostanes, as a marker of lipid peroxidation, may be involved in the development of impaired glucose tolerance (IGT) or diabetes. Using a nested case-control study, we tracked the changes in isoprostane levels, insulin sensitivity (IS) and beta-cell function (BCF) in Afro-Jamaicans who progr...

journal_title：Diabetes research and clinical practice

authors： Boyne MS,Sargeant LA,Bennett FI,Wilks RJ,Cooper RS,Forrester TE

更新日期：2007-04-01 00:00:00

abstract：:Glucose metabolism disturbances are frequently reported among patients with beta-thalassaemia major on conventional treatment consisted of regular blood transfusions and adequate chelation treatment. Aim of this study was to evaluate the evolution of oral glucose tolerance test (OGTT) in thalassaemic patients in relat...

journal_title：Diabetes research and clinical practice

authors： Christoforidis A,Perifanis V,Tsatra I,Vlachaki E,Athanassiou-Metaxa M

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Serum uric acid (UA) is reported as an important marker of hypertension, coronary heart disease, and diabetes; diabetic subjects have low UA levels. The relationship between UA and fasting plasma glucose (FPG) and 2-h plasma glucose concentrations in non-diabetic subjects as well as in diabetic subjects in ge...

journal_title：Diabetes research and clinical practice

authors： Nan H,Dong Y,Gao W,Tuomilehto J,Qiao Q

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The presence of diabetes in pregnancy can result in substantial morbidity to both mother and baby if management is sub-optimal. AIMS:To assess the process of standards of preconception care (against the National Service Framework standards) of women attending the adult general diabetes clinics in a district...

journal_title：Diabetes research and clinical practice

authors： Varughese GI,Chowdhury SR,Warner DP,Barton DM

更新日期：2007-04-01 00:00:00

abstract：:To investigate the effect of metabolic syndrome (MS) components on early atherosclerosis markers, i.e., urinary albumin excretion rate (UAE), pulse wave velocity (PWV), and carotid intima-media thickness (IMT), we studied 536 Japanese patients with type 2 diabetes without cardiovascular disease or nephropathy. The MS ...

journal_title：Diabetes research and clinical practice

authors： Yokoyama H,Kuramitsu M,Kanno S,Tada J,Yokota Y,Kamikawa F

更新日期：2007-02-01 00:00:00

abstract：BACKGROUND:To evaluate the efficacy of continuous glucose monitoring system (CGMS) to detect postprandial hyperglycemia and unrecognized hypoglycemia in type 1 diabetes mellitus (DM1) patients. METHODS:We studied 46 patients (43.4%M/56.6%F), average age of 25.9+/-12.8 years, submitted to 72 h CGMS. It were analyzed: c...

journal_title：Diabetes research and clinical practice

authors： Maia FF,Araújo LR

更新日期：2007-01-01 00:00:00

abstract：BACKGROUND:The relation between diabetes mellitus (DM) and mortality among patients with acute myocardial infarction is still controversial. We evaluated the influence of DM on the in-hospital mortality of acute myocardial infarction (AMI) patients using data from the Tokai Acute Myocardial Infarction Study-II, a multi...

journal_title：Diabetes research and clinical practice

authors： Hirakawa Y,Masuda Y,Kuzuya M,Iguchi A,Kimata T,Uemura K

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To investigate infection-related mortality and its predictors in Brazilian type 2 diabetic patients. METHODS:It was carried out a long-term prospective study with 471 type 2 diabetic outpatients. Several clinical, laboratory and electrocardiographic variables were recorded at baseline. Predictive factors for...

journal_title：Diabetes research and clinical practice

authors： Cardoso CR,Salles GF

更新日期：2007-01-01 00:00:00

abstract：:We aim to examine the short-term efficacy of a lifestyle intervention programme on cardiovascular risk factors in overweight urban Indigenous Australians with and without type 2 diabetes mellitus. One hundred and one urban Indigenous Australians in Queensland voluntarily participated in a culturally appropriate lifest...

journal_title：Diabetes research and clinical practice

authors： Chan LC,Ware R,Kesting J,Marczak M,Good D,Shaw JT

更新日期：2007-01-01 00:00:00

abstract：:Evaluation of a patient's pancreatic beta-cell function is important in both diagnosis and treatment of diabetes. We sought to determine beta-cell function with a single sampling of blood. Examination of fasting blood glucose (F-BG, mM) and C-peptide (F-CPR, nM) levels in seven post-islet-transplanted states of four p...

journal_title：Diabetes research and clinical practice

authors： Yamada Y,Fukuda K,Fujimoto S,Hosokawa M,Tsukiyama K,Nagashima K,Fukushima M,Suzuki H,Toyoda K,Sassa M,Funakoshi S,Inagaki N,Taniguchi A,Sato TS,Matsumoto S,Tanaka K,Seino Y

更新日期：2006-12-01 00:00:00

abstract：:We assessed the association between insulin resistance, overweight and metabolic disorders in a probabilistic sample of 388, 12-19-year-old girls from public schools in Niterói, Rio de Janeiro State, Brazil. Insulin resistance was determined using Homeostatic Model Assessment-Insulin Resistance (HOMA-IR). Overweight a...

journal_title：Diabetes research and clinical practice

authors： Alvarez MM,Vieira AC,Moura AS,da Veiga GV

更新日期：2006-11-01 00:00:00

abstract：:Diabetic retinopathy is associated with microvascular damage and capillary occlusions which are common features of the microangiopathy in diabetes. Monocyte-derived microparticles (MDMPs) are released from activated monocytes and enhance the procoagulant activity, and also activate adhesion reactions. These are key ev...

journal_title：Diabetes research and clinical practice

authors： Ogata N,Nomura S,Shouzu A,Imaizumi M,Arichi M,Matsumura M

更新日期：2006-09-01 00:00:00

abstract：:Gestational diabetes mellitus (GDM) is a transient metabolic disorder that is a strong predictor of type 2 diabetes and cardiovascular disease. Previously, GDM was associated with reduced red cell long-chain omega-6 and omega-3 fatty acids in population (British) with high intake of total and saturated fat. The aim of...

journal_title：Diabetes research and clinical practice

authors： Min Y,Nam JH,Ghebremeskel K,Kim A,Crawford M

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND:The aim of this study was to compare the effect of glycaemic control on oxidative stress and biochemical markers of endothelial activation in type 1 diabetic children. METHODS:Serum total cholesterol, HDL cholesterol, VLDL cholesterol, apolipoprotein A1, apolipoprotein B, HbA(1c), MDA, VEGF, NO, ICAM levels...

journal_title：Diabetes research and clinical practice

authors： Seckin D,Ilhan N,Ilhan N,Ertugrul S

更新日期：2006-08-01 00:00:00

abstract：:Apoptosis and its associated regulatory mechanisms are physiological events crucial to the maintenance of placental homeostasis; imbalance of these processes, however, such as occurs under various pathological conditions, may compromise placenta function and, consequently, pregnancy success. Increased apoptosis occurs...

journal_title：Diabetes research and clinical practice

authors： Sgarbosa F,Barbisan LF,Brasil MA,Costa E,Calderon IM,Gonçalves CR,Bevilacqua E,Rudge MV

更新日期：2006-08-01 00:00:00

abstract：:Corosolic acid (CRA) is a substance extracted from Lagerstroemia speciosa L. and has been reported to have biological activities in in vitro and experimental animal studies. In this study, 31 subjects were orally administered 10mg CRA or a placebo, on different occasions, in a capsule 5min before the 75-g oral glucose...

journal_title：Diabetes research and clinical practice

authors： Fukushima M,Matsuyama F,Ueda N,Egawa K,Takemoto J,Kajimoto Y,Yonaha N,Miura T,Kaneko T,Nishi Y,Mitsui R,Fujita Y,Yamada Y,Seino Y

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND AIMS:The data regarding comparison of efficacy of metformin with glimepiride, newest Sulfonylurea, or with the use of both drugs in combination with insulin is rare in the literature. Therefore, we assessed the daily insulin dose, hypoglycemic events and body weight on achieving desirable glycemic contro...

journal_title：Diabetes research and clinical practice

authors： Kabadi UM,Kabadi M

更新日期：2006-06-01 00:00:00

abstract：:This study was done to see whether 27-base pair repeats polymorphism in intron 4 of ecNOS gene is associated with carotid atherosclerosis in type 2 diabetic patients. The polymorphism was identified by polymerase chain reaction (PCR). Ultrasound parameters of carotid atherosclerosis were analyzed in relation to the ge...

journal_title：Diabetes research and clinical practice

authors： Park JH,Kim JH,Kim WH,Kim DS,Park TS,Baek HS

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVE:The aim of our work was to carry out a randomized clinical trial with a fast-food Mediterranean type diet rich in platelet activating factor (PAF) antagonist to investigate the effect on type 2 diabetics and healthy human subject's platelet aggregation. RESEARCH DESIGN AND METHODS:We extracted lipids from fa...

journal_title：Diabetes research and clinical practice

authors： Karantonis HC,Fragopoulou E,Antonopoulou S,Rementzis J,Phenekos C,Demopoulos CA

更新日期：2006-04-01 00:00:00

abstract：:We studied the efficacy of four different treatment regimens (sulphonylurea and metformin+/-acarbose versus glimepiride and rosiglitazone versus glimepiride and bedtime NPH insulin versus multiple actrapid and NPH insulin injections) in poorly controlled type 2 diabetes subjects on hs-CRP, VCAM-1 and AGE at 4, 8 and 1...

journal_title：Diabetes research and clinical practice

authors： Md Isa SH,Najihah I,Nazaimoon WM,Kamarudin NA,Umar NA,Mat NH,Khalid BA

更新日期：2006-04-01 00:00:00

abstract：AIMS:To examine the association between habitual snoring and components of the metabolic syndrome in Korean adults. Whether these associations are independent of obesity was also explored. METHODS:Four thousand five hundred and six men and 5041 women aged 40-69 years from the Korean Health and Genome Study were examin...

journal_title：Diabetes research and clinical practice

authors： Cho N,Joo S,Kim J,Abbott RD,Kim J,Kimm K,Shin C

更新日期：2006-03-01 00:00:00

abstract：:The current study evaluates the indices of glucose control for diabetics (i.e., glycated albumin (GA), hemoglobin A1c (HbA1c), plasma glucose (PG) and immuno-reactive insulin (IRI)) in non-diabetic children from a population-based cohort, and compares those values according to the presence of obesity to examine any di...

journal_title：Diabetes research and clinical practice

authors： Nishimura R,Kanda A,Sano H,Matsudaira T,Miyashita Y,Morimoto A,Shirasawa T,Kawaguchi T,Tajima N

更新日期：2006-03-01 00:00:00

abstract：:Our aim was to see the levels of lipoprotein (a) (Lp (a)) in patients with gangrenous or non-gangrenous diabetic foot lesions. Twenty-two patients with gangrenous foot lesions, 11 with non-gangrenous foot lesions and 10 healthy subjects were included in the study. All the patients had similar glycemic control and dura...

journal_title：Diabetes research and clinical practice

authors： Unlühizarci K,Muhtaroğlu S,Kabak S,Bayram F,Keleştimur F

更新日期：2006-02-01 00:00:00

abstract：:The aim of this cross-sectional study was to describe the prevalence of total, known and unknown diabetes mellitus and impaired fasting glucose (IFG) in the population of Murcia (SE Spain), a Mediterranean area with a high prevalence of obesity. Therefore, 2562 subjects (>or=20 years) were selected by stratified rando...

journal_title：Diabetes research and clinical practice

authors： Valverde JC,Tormo MJ,Navarro C,Rodríguez-Barranco M,Marco R,Egea JM,Pérez-Flores D,Ortolá JB,González-Sicilia L,Tébar J,Sánchez-Pinilla M,Flores M,Cava J

更新日期：2006-02-01 00:00:00

abstract：:The recurrence rate of GDM among women in Japan who had GDM or one abnormal value on 75 g oral glucose tolerance test (OAV) during an initial pregnancy is unclear. We therefore sought to determine the recurrence rate and risk factors of recurrent GDM by evaluating 32 patients with GDM and 37 with OAV in their index pr...

journal_title：Diabetes research and clinical practice

authors： Nohira T,Kim S,Nakai H,Okabe K,Nohira T,Yoneyama K

更新日期：2006-01-01 00:00:00

abstract：:We describe here four male patients with long-term and poorly controlled type 2 diabetes mellitus. They shared many common characteristic complications, such as severe autonomic neuropathy, proliferative retinopathy and normocytic normochromic anemia without progressive renal failure and macroangiopathy. They also sho...

journal_title：Diabetes research and clinical practice

authors： Saito T,Tojo K,Morimoto A,Tajima N

更新日期：2005-12-01 00:00:00

abstract：:The study analyzed the clinical background and eating habits of Japanese youth-onset type 2 diabetes. Thirty-six patients with type 2 diabetes (22 males, 14 females) with onset in less than 20-year-old were studied. All patients were negative for anti-glutamic acid decarboxylase (GAD) antibody and islet cell antibody....

journal_title：Diabetes research and clinical practice

authors： Matsui J,Tamasawa N,Tanabe J,Kasai N,Murakami H,Matsuki K,Suda T

更新日期：2005-12-01 00:00:00

abstract：OBJECTIVE:To test the association of undiagnosed Type 2 diabetes mellitus with education and income level. METHODS:We utilized measures of diabetes status, fasting plasma glucose, socio-economic status, and demographic characteristics from the National Health and Nutrition Examination Survey (NHANES III) for adults of...

journal_title：Diabetes research and clinical practice

authors： Wilder RP,Majumdar SR,Klarenbach SW,Jacobs P

更新日期：2005-10-01 00:00:00

abstract：:Although persistent proteinuria is characteristic of diabetic nephropathy (DN), it is important to differentiate non-diabetic renal diseases (NDRD) in diabetic patients with proteinuria. In order to re-evaluate the indications for renal biopsy in the diabetic patients, we retrospectively analyzed the relationship betw...

journal_title：Diabetes research and clinical practice

authors： Tone A,Shikata K,Matsuda M,Usui H,Okada S,Ogawa D,Wada J,Makino H

更新日期：2005-09-01 00:00:00

abstract：:Wistar fatty (WF) rats are obese, hyperinsulinemic and hyperglycemic, and thus a model of type 2 diabetes mellitus. Since we have found that insulin specifically inhibits glucagon-induced glycogenolysis in perivenous hepatocytes (PVH) from normal rats, we examined the inhibitory effect of insulin on glucagon-induced g...

journal_title：Diabetes research and clinical practice

authors： Ikezawa Y,Yamatani K,Ohnuma H,Daimon M,Manaka H,Sasaki H

更新日期：2005-08-01 00:00:00

abstract：:There are scant data from African populations on the association between beta-cell function and response to treatment with oral hypoglycaemic agents in Type 2 diabetes mellitus (T2DM). Fasting plasma C-peptide (FCP) and glucagon-stimulated C-peptide (GSCP) levels were measured in 116 Nigerians with T2DM at a universit...

journal_title：Diabetes research and clinical practice

authors： Oli JM,Adeyemo AA,Okafor GO,Ofoegbu EN,Onyenekwe B,Chukwuka CJ,Chen G,Chen Y,Doumatey AP,Aje TO,Rotimi CN

更新日期：2005-08-01 00:00:00

abstract：:The aim of this study was to determine the 10-year mortality rate of an elderly population aged 70 years or over (n=379) with reference to glucose tolerance status, taking into account other determinants of excess mortality. The baseline examination during 1991-1992 included a postal questionnaire, a physical examinat...

journal_title：Diabetes research and clinical practice

authors： Hiltunen L

更新日期：2005-07-01 00:00:00

abstract：:Diabetic retinopathy is caused by capillary occlusions. Platelet-derived microparticles (PMPs) stimulate the coagulation cascade and increase leukocyte and endothelial cell adhesions, both of which are key events in the development of diabetic retinopathy. However, the correlation between the levels of PMPs and diabet...

journal_title：Diabetes research and clinical practice

authors： Ogata N,Imaizumi M,Nomura S,Shozu A,Arichi M,Matsuoka M,Matsumura M

更新日期：2005-06-01 00:00:00